منابع مشابه
Lysosome-targeting agents in cancer therapy
Despite considerable efforts from multiple laboratories worldwide, highly specific inhibitors of autophagy for clinical use are not yet available. Lysosomal inhibitors are being employed instead, in spite of multiple limitations that are summarized herein.
متن کاملThe Role of miRNA Dysregulation in Thyroid Cancer Development by Targeting the Main Signaling Pathways
Thyroid cancer is one of the most common malignancies of endocrine glands, causing carcinomas, such as papillary, follicular, medullary, and anaplastic thyroid carcinomas. Due to the significance of thyroid carcinomas, identification of the main signaling pathways and the affecting mutations has been considered by researchers. Further studies on the dysregulation of oncogenes in signaling path...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولThe Effect of Plant-derived Compounds in Targeting Cancer Stem Cells
Background Cancer stem cells (CSCs) are a small subpopulation of cancer cells with self-renewal and differentiation ability. Furthermore, CSCs are resistant to chemoradiotherapy due to their high level of detoxifying enzymes, strong DNA repair abilities, and high drug efflux capacity. Objective Therefore, CSCs are supposed to account for cancer initiation, progression, metastasis, recurrence, ...
متن کاملUtilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXphi targeting signals.
A systematic study was conducted on the requirements at the C-terminal position for the targeting of LAMPs to lysosomes, examining the hypothesis that a bulky hydrophobic residue is required. Mutations deleting or replacing the C-terminal valine with G, A, C, L, I, M, K, F, Y, or W were constructed in a reporter protein consisting of the lumenal/extracellular domain of avian LAMP-1 fused to the...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2015
ISSN: 0077-8923
DOI: 10.1111/nyas.12953